CareLoop scales clinical deployment and team growth following NPIF II investment

Manchester-based CareLoop Health is reporting strong early traction following a £1.8m funding round from NPIF II – PXN Equity Finance, the GMC Life Sciences Fund by PXN Ventures, Verge HealthTech Fund and SFC Capital, supporting the business to scale its technology and expand clinical adoption across the UK and internationally.

Launched in 2021, Careloop Health is a University of Manchester spinout focused on transforming care in  severe mental illness, including schizophrenia and psychosis. Built on more than a decade of research and clinical trials prior to spinout, the CareLoop digital platform integrates into existing care pathways, enabling clinicians to remotely monitor patients while using algorithm-driven insights to predict and prevent relapses.

Since securing the investment in 2025, CareLoop Health has grown its team from two to ten employees, strengthening its clinical, technical and commercial capabilities as it moves towards wider adoption. The business has also secured an SBRI Healthcare grant along with funding from NHS England, enabling pilot programmes across five NHS trusts, while building a strong commercial pipeline as it looks to convert pilots into long-term contracts. The company’s growth reflects increasing momentum across the UK’s digital health and life sciences sectors, both identified as priority areas in the UK’s Modern Industrial Strategy.

Alongside its UK growth, CareLoop Health has begun expanding internationally, with two sites in the United States. The company has also been accepted into the NHS Innovation Accelerator, with COO Dr Pauline Whelan awarded a fellowship.

CareLoop Health’s technology uses daily patient-reported data to identify early warning signs of deterioration, with a 50% reduction in relapse rates. The platform has also been recognised by NICE through its Early Value Assessment programme, highlighting its potential to deliver significant cost savings and improved outcomes for the NHS.

Looking ahead, the business plans to build on its growing traction across the UK, focusing on converting pilot programmes into commissioned services and working towards making its technology a standard part of care for severe mental illness. It will also continue to develop its platform to support additional conditions.

Zoë Blake, Founding CEO of CareLoop Health, said: “NPIF II has given us the breathing space to grow our team and work much more closely with NHS partners as we move CareLoop into  clinical use. It’s helped us take years of research and start turning it into something that’s being used day-to-day in services. We’re now focused on building on that momentum and expanding access for more people with severe mental illness.”

Louise Chapman, Fund Manager at PXN Ventures, said: “It’s been really positive to see the progress CareLoop Health has made since our investment, building out its team and continuing to develop a platform that is now being used in NHS settings through a number of pilot programmes. The business has taken a strong, evidence-led approach from the outset and what stands out is how that foundation is now translating into real-world clinical use.”

Sue Barnard, Senior Investment Manager at the British Business Bank, said: “CareLoop Health is helping to demonstrate the strength of the North West’s digital health and life sciences sectors, which is a key part of the UK’s Modern Industrial Strategy to drive nationwide growth. Through NPIF II, we’re continuing to back ambitious companies across the North that are leading the way in innovation, providing new solutions and allowing us to compete on an international stage.”

The £660m Northern Powerhouse Investment Fund II (NPIF II) covers the entire North of England and provides loans from £25k to £2m and equity investment up to £5m to help a range of small and medium sized businesses to start up, scale up or stay ahead.

The purpose of the Northern Powerhouse Investment Fund II is to drive sustainable economic growth by supporting innovation and creating local opportunity for new and growing businesses across the North of England. The Northern Powerhouse Investment Fund II will increase the supply and diversity of early-stage finance for the North’s smaller businesses, providing funds to firms that might otherwise not receive investment and help to break down barriers in access to finance.